The authors of a new study make the case that Alzheimer’s disease is driven by diet, and that an evolutionary survival response to forage for food triggered by the production of fructose in the brain back in cave man days has now gone haywire due to the abundance of fructose in the modern food supply. Listen in this week as Dee discusses the findings of the study, and what this means for prevention and treatment of Alzheimer’s disease.


Johnson, R. J., Tolan, D. R., Bredesen, D., Nagel, M., Sánchez-Lozada, L. G., Fini, M., Burtis, S., Lanaspa, M. A., & Perlmutter, D. (2023). Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? The American Journal of Clinical Nutrition, 117(3), 455–466.